Life science publications
Life science publications
603 | 2018 | Carta A., Sanna G., Briguglio I., Madeddu S., Vitale G., Piras S., Corona P. Peana A.T., Laurini E., Fermeglia M., Pricl S., Serra A., Carta E., Loddo R., Giliberti G. | 2018; https://doi.org/10.1016/j.ejmech.2017.12.083 | European Journal of Medicinal Chemistry |  | Quinoxaline derivatives as new inhibitors of coxsackievirus B5 | 602 | 2018 | Marson D,. Laurini E., Fermeglia M., Smith D.K., Pricl S. | 2018; DOI https://doi.org/10.1016/j.fluid.2017.11.005 | Fluid Phase Equilibria | | Mallard Blue binding to heparin, its SDS micelle-driven de-
complexation, and interaction with human serum albumin: A
combined experimental/modeling investigation | 593 | 2017 | Weber F, Brust P, Laurini E, Pricl S, Wünsch B | 2017;964:31-48 | Advances in Experimental Medicine and Biology | | Fluorinated PET tracers for molecular imaging of σ1 receptors in the central nervous system | 600 | 2017 | Rodrigo A.C., Laurini E., Vieira V.M.P., Pricl S., Smith D.K. | 2017;53,11580-11583 | Chemical Communications | | Effect of buffer at nanoscale molecular recognition interfaces - electrostatic binding of biological polyanions | 590 | 2017 | Rodrigo AC, Bromfield SM, Laurini E, Posocco P, Pricl S, Smith DK | 2017;53(47):6335-6338 | Chemical Communications | | Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media | 591 | 2017 | Albanyan B, Laurini E, Posocco P, Pricl S, Smith DK | 2017;23(26):6391-6397 | Chemistry - A European Journal | | Self-assembled multivalent (SAMul) polyanion binding-impact of hydrophobic modifications in the micellar core on DNA and heparin binding at the peripheral cationic ligands | 586 | 2017 | Wünsch B, Kokornaczyk A, Schepmann D, Yamaguchi J, Itami K, Laurini E, Fermeglia M, Pricl S | 2017; 12, 1070-1080 | ChemMedChem | | Thiazole-based sigma-1 receptor ligands: Diversity by late-stage C-H arylation of thiazoles, structure affinity and selectivity relationships and molecular interactions | 604 | 2017 | Chiarappa G., Piccolo A., Colombo I., Hasa D., Voinovich D., Moneghini M., Grassi G., Farra R., Abrami M., Posocco P., Pricl S., Grassi M. | 2017;17, 4072-4083 | Crystal Growth & Design | | Exploring the Shape Influence on Melting Temperature, Enthalpy,
and Solubility of Organic Drug Nanocrystals by a Thermodynamic
Model | 601 | 2017 | Briguglio I., Laurini E., Pirisi M.A., Piras S., Corona P., Fermeglia M., Pricl S., Carta A. | 2017;141,460-472 | European Journal of Medicinal Chemistry | | Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics | 595 | 2017 | Laurini E, Marson D, Fermeglia M, Pricl S | 2017; 244,27-50 | In "Handbook of experimental Pharmacology", eds. F.J Kim and G.W. Pasternak, Springer 2017 |  | 3D homolgy model of sigma 1 receptor | 594 | 2017 | Vieira VMP, Liljeström V, Posocco P, Laurini E, Pricl S, Kostiainen MA, Smith DK | B, 2017;5(2):341-347 | Journal of Materials Chemistry | | Emergence of highly-ordered hierarchical nanoscale aggregates on electrostatic binding of self-assembled multivalent (SAMul) cationic micelles with polyanionic heparin | 587 | 2017 | Colombo C, Belfiore A, Paielli N, De Cecco L, Canevari S, Laurini E, Fermeglia M, Pricl S, Verderio P, Bottelli S, Fiore M, Stacchiotti S, Palassini E, Gronchi A, Pilotti S, Perrone F | 2017; 11, 1495-1507 | Molecular Oncology | | β-catenin in desmoid-type fibromatosis: deep insights on the role of T41A and S45F mutations on protein structure and gene expression | 588 | 2017 | Andrieu C, Ziouziou H, Laurini E, Karaki S, Baylot V, Fermeglia M, Dusetti N, Camplo M, Siri O, Pricl S, Katsogiannou M, Rocchi P | 2017; 8,77317-77329 | Oncotarget | | Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment | 589 | 2017 | Perfetti V, Laurini E, Aulic S, Fermeglia M, Riboni R, Lucioni M, Dallera E, Delfanti S, Pugliese L, Latteri FS, Pietrabissa A, Pricl S | 2017; 8:56158-56167 | Oncotarget | | Molecular and functional characterization of a new 3’ end KIT juxtamembrane deletion in a duodenal GIST treated with neoadjuvant Imatinib | 585 | 2017 | Genini D, Brambilla L, Laurini E, Merulla J, Civenni G, Pandit S, D'Antuono R, Perez L, Levy DE, Pricl S, Carbone GM, Catapano CV | 2017; 114, e4924-e4933 | Proceedings of the National Academy of Science (PNAS) | | Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells | 579 | 2016 | Chan, Ching W.; Laurini, Erik; Posocco, Paola; Pricl, Sabrina; Smith, David K. | 2016; 52:10540-10543 | Chemical Communications | | Chiral recognition at self-assembled multivalent (SAMul) nanoscale interfaces – enantioselectivity in polyanion binding | 577 | 2016 | Fechner, LE; Albanyan, B; Vieira, VMP; Laurini, E; Posocco, P; Pricl, S; Smith, DK | 2016; 7:4653-4659 | Chemical Science | | Electrostatic binding of polyanions using self-assembled multivalent (SAMul) ligand displays – structure–activity effects on DNA/heparin binding
| 571 | 2016 | A. Carta, I. Briguglio, S. Piras, P. Corona, R. Ibba, E. Laurini, M. Fermeglia, S. Pricl, N. Desideri, E.M. Atzori, P. La Colla, G. Collu, I. Delogu, R. Loddo | 2016;117: 321-334 | European Journal of Medicinal Chemistry |  | A combined in silico/in vitro approach unveils common molecular
requirements for efficient BVDV RdRp binding of linear aromatic
N-polycyclic systems | 573 | 2016 | Zampieri, Daniele; Vio, Luciano; Fermeglia, Maurizio; Pricl, Sabrina; Wünsch, Bernhard; Schepmann, Dirk; Romano, Maurizio; Mamolo, Maria Grazia; Laurini, Erik | 2016; 121:712-726 | European Journal of Medicinal Chemistry | | Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands | 566 | 2016 | E. Laurini, D. Marson, P. Posocco, M. Fermeglia, S. Pricl | 2016; 422:18-31 | Fluid Phase Equilibria |  | Structure and binding thermodynamics of viologen-phosphorous dendrimers to human serum albumin: a combined computational/experimental investigation. | 580 | 2016 | Estrada, Martín; Pérez, Concepción; Soriano, Elena; Laurini, Erik; Romano, Maurizio; Pricl, Sabrina; García, José A Morales; Pérez-Castillo, Ana; Rodríguez-Franco, María Isabel | 2016; 8:1191-1207 | Future Medicinal Chemistry | | New neurogenic lipoic-based hybrids as innovative Alzheimer’s drugs with σ-1 agonism and β-secretase inhibition | 578 | 2016 | Weber, Frauke; Brune, Stefanie; Börgel, Frederik; Korpis, Katharina; Lange, Carsten; Bednarski, Patrick J; Laurini, Erik; Fermeglia, Maurizio; Pricl, Sabrina; Schepmann, Dirk; Wünsch, Bernhard | 2016; 59:5505-5519 | Journal of Medicinal Chemistry | | Rigidity versus flexibility: is this an issue in S1 (sigma-1) receptor ligand affinity and activity? | 562 | 2016 | Beiranvand Z, Bani F, Kakanejadifard A, Laurini E, Fermeglia M, Pricl S, Adeli M. | 2016; 6:11266-11277. | RSC Advances | | Anticancer drug delivery systems based on specific interactions between albumin and polyglicerol | 570 | 2016 | Chen C, Posocco P., Liu X., Cheng Q.,Laurini E., Zhou J., Liu C., Wang Y., Tang J., Dal Col V., Yu T., Giorgio S., Fermeglia M., Qu F., Liang Z., Rossi J.J., Liu M., Rocchi P., Pricl S., Peng L. | 2016; 12:3667-3676 | Small |  | Mastering Dendrimer Self-Assembly for Effi cient siRNA Delivery: From Conceptual Design to In Vivo Effi cient
Gene Silencing | 554 | 2015 | Briguglio I, Loddo R, Laurini E, Fermeglia M, Piras S, Corona P, Giunchedi P, Gavini E, Sanna G, Giliberti G, Ibba C, Farci P, La Colla P, Pricl S, Carta A. | 2015; 105:63-79. | European Journal of Medicinal Chemistry | | Synthesis, citotoxicity and antiviral evaluation of new sereis of imidazo[4,5-g]quinoline and pyrido[2,3-g]quinoxalinone derivatives | 540 | 2015 | Zampieri D,, Laurin E, Vio L, Fermeglia M, Pricl S, Wuensch B, Schepmann D, Mamolo MG., | 2015;90:797-808. | European Journal of Medicinal Chemistry | | Improving selectivity preserving affinity: New piperidine-4-carboxamide derivatives as effective sigma-1-ligands. | 539 | 2015 | Rossi D, Marra A, Rui M, Laurini E, Fermeglia M, Pricl S, Schepmann D, Wuensch B, Peviani M, Curti D, Collina S., | 2015,6,138-146. | MedChemComm | | A step forward in the sigma enigma: a role for chirality in the sigma1 receptor–ligand interaction?
| 545 | 2015 | Brambilla L, Genini D, Laurini E, Merulla J, Perez L, Fermeglia M, Carbone GM, Pricl S, Catapano CV | 2015;9(6):1194-1206. | Molecular Oncology | | Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3) | 531 | 2015 | Pricl S, Cortelazzi B, Dal Col V, Marson D, Laurini E, Fermeglia M, Licitra L, Pilotti S, Bossi P, Perrone F | 2015;9(2):389-397. | Molecular Oncology | | Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma | 553 | 2015 | Morgan A, Gandin I, Belcaro C, Palumbo P, Palumbo O, Biamino E, Dal Col V, Laurini E, Pricl S, Bosco P, Carella M, Ferrero GB, Romano C, D'Adamo AP, Faletra F, Vozzi D. | 2015; 781:32-36. | Mutation Research | | Targeting sequencing approach intended to discover new mutations in non.syndromic intellectual disability | 532 | 2015 | Marson D, Laurini E, Poocco P, Fermeglia M, Pricl S | 2015;7(9):3876-3887. | Nanoscale |  | Cationic carbosilane dendrimers and oligonucleotide binding: an energetic affair | 541 | 2015 | Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang X, Rocchi P, Peng L. | 2015;112(10):2978-2983. | Proceedings of the National Academy of Science (PNAS) |  | Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. | 552 | 2015 | Mehrabadi, FS, Hirsch, O, Zeisig, R, Posocco, P, Laurini E, Pricl, S, Haag, R, Kemmer, W, Calderon. M. | 2015; 5:78760-78770. | RSC Advances | | Structure-activity relationship study of dendriric polyglycerolamines for efficient siRNA transfection | 510 | 2014 | Tintaru A., Chendo C., Wang Q., Viel S., Quéléver G., Peng L., Posocco P., Pricl, S. , Charles L. | 2014;808:163-74. | Analytica Chimica Acta | | Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study | 528 | 2014 | Liu X, Zhou J, Yu T, Chao Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Cheng Liu C, Yang Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi JJ,Peng L | 2014;53(44):11822-11827. | Angewandte Chemie | | Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems | 523 | 2014 | Brune S, Schepmann D, Klempnauer K-H, Marson D, Dal Col V, Laurini E, Fermeglia M, Wünsch B, Pricl S | 2014;53(18):2993-3003. | Biochemistry | | The sigma enigma: in silico/in vitro site directed mutagenesis studies unveil σ1 receptor ligand binding. | 519 | 2014 | Zampieri D, Laurini E, Vio L, Golob S, Fermeglia M, Pricl S, Mamolo MG. | 2014;24(4):1021-5. | Bioorganic & Medicinal Chemistry Letters | | Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands. | 517 | 2014 | Bromfield SM, Posocco P, Chan CW, Calderon M, Guimond SE, Turnbull JE, Pricl S, Smith DK. | 2014;5:1484-92. | Chemical Science | | Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media | 526 | 2014 | Bromfield SM, Posocco P, Fermeglia M, Tolosa J, Herreros-López A, Pricl S, Rodríguez-López J, Smith DK. | 2014;20(31):9666-74. | Chemistry - A European Journal | | Shape-persistent and adaptive multivalency: rigid transgeden (TGD) and flexible PAMAM dendrimers for heparin binding. | 527 | 2014 | Laurini E, Harel D, Marson D, Schepmann D, Schmidt TJ, Pricl S, Wünsch B. | 2014;83:526-33. | European Journal of Medicinal Chemistry | | Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands. | 520 | 2014 | Weber F, Brune S, Korpis K, Bednarski PJ, Laurini E, Dal Col V, Pricl S, Schepmann D, Wünsch B. | 2014;57(7):2884-94. | Journal of Medicinal Chemistry | | Synthesis, Pharmacological Evaluation, and σ1 Receptor Interaction Analysis of Hydroxyethyl Substituted Piperazines. | 521 | 2014 | Kala S, Mak AS, Liu X, Posocco P, Pricl S, Peng L, Wong AS. | 2014;57(6):2634-42. | Journal of Medicinal Chemistry | | Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target akt with the clinical anticancer drug Paclitaxel for effective and potent anticancer activity in treating ovarian cancer. | 524 | 2014 | Wang Y, Liu X, Laurini E, Posocco P, Ziarelli F, Fermeglia M, Qu F, Pricl S, Zhang C-C-,Peng L | 2014;12(26):4723-4729. | Organic & Biomolecular Chemistry |  | Mimicking 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
| 513 | 2014 | Barnard A., Posocco P., Fermeglia M., Tschiche A., Calderon M., Pricl S., Smith D.K. | 2014;12:446-55. | Organic & Biomolecular Chemistry | | Double-degradable responsive self-assembled multivalent arrays - temporary nanoscale recognition between dendrons and DNA | 518 | 2014 | Gibbons DL, Pricl S, Posocco P, Laurini E, Fermeglia M, Sun H, Talpaz M, Donato N, Quintás-Cardama A. | 2014;111(9):3550-5. | Proceedings of the National Academy of Science (PNAS) | | Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy. | 495 | 2013 | Rossi D, Pedrali A, Gaggeri R, Marra A, Pignataro L, Laurini E, Dal Col V, Fermeglia M, Pricl S, Schepmann D, Wünsch B, Peviani M, Curti D, Collina S. | 2013;21(9):2577-86. | Bioorganic & Medicinal Chemistry | | Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability | 498 | 2013 | Laurini E, Dal Col V, Wunsch B, Pricl S | 2013;23(10):2868-71. | Bioorganic & Medicinal Chemistry Letters | | Analysis of the molecular interactions of the potent analgesic S1RA with the σ1 receptor | 494 | 2013 | Amadio M., Pascale A., Govoni S., Laurini E., Pricl S., Gaggeri R., Rossi D., Collina S. | 2013;81(6):707-14. | Chemical Biology & Drug Design | | Identification of peptides with ELAV-like mRNA stabilizing effect: an
integrated in vitro/in silico approach | 499 | 2013 | Bromfield SM, Posocco P, Fermeglia M, Pricl S, Rodriguez-Lopez J, Smith DK | 2013;49(42):4830-2. | Chemical Communications |  | A simple new competition assay for heparin binding in
serum applied to multivalent PAMAM dendrimers | 508 | 2013 | Rossi D, Pedrali A, Gaggeri R, Marra A, Pignataro L, Laurini E, Dal Col V, Fermeglia M, Pricl S, Schepmann D, Wünsch B, Peviani M, Curti D, Collina S. | 2013;8(9):1514-27. | ChemMedChem | | Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: promising neuroprotective agents acting as σ1 receptor agonists | 515 | 2013 | Quéléver G., Bouillon C. , Moreno P., Tintaru A., Charles L. , Pricl S., Peng L. | 2013:167-178. | In Dendrimers in Biomedical Applications | | Poly(Aminoester) dendrimers: design, synthesis and characterization | 516 | 2013 | Liu X., Posocco P., Liu C., Yu T., Wang Q., Dal Col V., Chen C., Wang Y., Rocchi P., Pricl S., Peng L. | 2013:73-83. | In Dendrimers in Biomedical Applications | | Poly(amidoamine) (Pamam) Dendrimers as non‐viral vectors for the delivery of RNA therapeutics | 503 | 2013 | Brune S, Pricl S, Wünsch B. | 2013;56(24):9809-19. | Journal of Medicinal Chemistry | | Structure of the σ1 receptor and its ligand binding site | 492 | 2013 | Bromfield SM, Barnard A, Posocco P, Fermeglia M, Pricl S, Smith DK | 2013;135(8):2911–4. | Journal of the American Chemical Society |  | Mallard Blue – A High-Affinity Selective Heparin Sensor which Operates in Highly-Competitive Media | 507 | 2013 | Bozzi F, Conca E, laurini E, Posocco P, Lo Sardo A, Jocollè G, Sanfilippo R, Gronchi A, Perrone F, Tamborini E., Pelosi G, Pierotti MA, Maestro R, Pricl S, Pilotti S. | 2013;93(11):1232-40. | Laboratory Investigation | | In vitro and in silico studies of MDM2/MDMX isoforms predict Nutilin-3A sensitivity in well/de-differentiated liposarcomas | 496 | 2013 | Conca E, Miranda C, Dal Col V, Fumagalli E, Pelosi G, Mazzoni M, Fermeglia M, Laurini E, Pierotti MA, Pilotti S, Greco A, Pricl S, Tamborini E. | 2013;7(4):756-62. | Molecular Oncology | | Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib | 504 | 2013 | Laurini E, Posocco P, Fermeglia M, Gibbons DL, Quintás-Cardama A, Pricl S. | 2013;7(5):968-75. | Molecular Oncology | | Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments | 505 | 2013 | Posocco P, Liu X, Laurini E, Marson D, Chen C, Liu C, Fermeglia M, Rocchi P, Pricl S, Peng L. | 2013;10(8):3262-73. | Molecular Pharmaceutics | | Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing | 497 | 2013 | Welsh DJ, Posocco P, Pricl S, Smith DK. | 2013;11(19):3177-86. | Organic & Biomolecular Chemistry |  | Self-assembled multivalent RGD-peptide arrays – morphological control and integrin binding | 509 | 2013 | X. Liu, Y. Wang, E. Laurini, P. Posocco, H. Chen, F. Ziarelli, A. Janicki, F. Qu,M. Fermeglia, S.Pricl, C.-C. Zhang. L.Peng | 2013,15(18):4662-5. | Organic Letters |  | Structural requirements of 2‑oxoglutaricacid analogues to mimic its signaling
function | 512 | 2013 | Ottaviani M.F., Cangiotti M., Fattori A., Coppola C., Posocco P., Laurini E., Liu X., Liu C., Fermeglia M., Peng L., Pricl S. | 2014;16(2):685-94. | Physical Chemistry Chemical Physics | | Copper(ii) binding to flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach | 474 | 2012 | Gibbons DL, Pricl S, Kantarjian H, Cortes J, Quintás-Cardama A. | 2012;118:293-9. | Cancer |  | The rise and fall of gatekeeper mutations? The BCR-ABL1 T315I paradigm | 484 | 2012 | Posocco P, Laurini E, Col VD, Marson D, Karatasos K, Fermeglia M, Pricl S. | 2012;19:5062-87. | Current Medicinal Chemistry |  | Tell Me Something I Do Not Know. Multiscale Molecular Modeling of Dendrimer/Dendron Organization and Self-Assembly In Gene Therapy. | 478 | 2012 | Meyer C, Schepmann D, Yanagisawa S, Yamaguchi J, Dal Col V, Laurini E, Itami K, Pricl S, Wünsch B | 2012;55(18):8047–65. | Journal of Medicinal Chemistry | | Pd-catalyzed direct C-H bond functionalization of spirocyclic sigma-1 ligands: generation of a pharmacophore model and analysis of reverse binding mode by docking into a 3D homology model of the sigma-1 receptor. | 469 | 2012 | Karatasos K, Posocco P, Laurini E, Pricl S. | 2012, 12(2):225-40. | Macromolecular Bioscience | | Poly(amidoamine)-based Dendrimer/siRNA Complexation Studied by Computer Simulations: Effects of pH and Generation on Dendrimer Structure and siRNA Binding. | 487 | 2012 | Laurini E, Marson D, Dal Col V, Fermeglia M, Mamolo MG, Zampieri D, Vio L, Pricl S. | 2012;9(11):3107-26. | Molecular Pharmaceutics | | Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands | 468 | 2012 | Liu X, Liu C, Laurini E, Posocco P, Pricl S, Qu F, Rocchi P, Peng L. | 2012;9(3):470-81. | Molecular Pharmaceutics |  | Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer | 476 | 2011 | Erik Laurini, Valentina Dal Col, Maria Grazia Mamolo, Daniele Zampieri, Paola Posocco, Maurizio Fermeglia, Luciano Vio, Sabrina Pricl | 2011;2:834-839. | ACS Medicinal Chemistry Letters |  | Homology Model and Docking-Based Virtual Screening for Ligands of the sigma 1 Receptor. | 473 | 2011 | Liu X, Wu J, Yammine M, Zhou J, Posocco P, Viel S, Liu C, Ziarelli F, Fermeglia M, Pricl S, Victorero G, Nguyen C, Erbacher P, Behr JP, Peng L. | 22:2461-73 (2011) | Bioconjugate Chemistry |  | Structurally flexible triethanolamine core PAMAM dendrimers are effective nanovectors for DNA transfection in vitro and in vivo to the mouse thymus | 443 | 2011 | Dileo P., Pricl S., Tamborini E., Negri T., Stacchiotti S., Gronchi A., Posocco P., Laurini E., Coco P., Fumagalli E., Casali P.G., Pilotti S. | 128:983-90 (2011) | International Journal of Cancer |  | Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: An imaging, biochemical and molecular modeling study | 471 | 2011 | Barnard A, Posocco P, Pricl S, Calderon M, Haag R, Hwang ME, Shum VW, Pack DW, Smith DK. | 2011;133:20288-300. | Journal of the American Chemical Society |  | Degradable self-assembling dendrons for gene delivery: experimental and theoretical insights into the barriers to cellular uptake. | 457 | 2011 | Jones S..P, Gabrielson N.P., Wong C.H., Chow H.F., Pack D.W., Posocco P., Fermeglia M., Pricl S., Smith D.K. | 8:416-29 (2011) | Molecular Pharmaceutics |  | Hydrophobically Modified Dendrons: Developing Structure-Activity Relationships for DNA Binding and Gene Transfection | 458 | 2011 | Pierotti M., Tamborini E., Negri T., Pricl S., Pilotti S. | 2011;8:161-170. | Nature Reviews Clinical Oncology |  | Targeted therapy in GIST: in silico modeling for prediction of resistance | 475 | 2011 | Liu X, Chen H, Laurini E, Wang Y, Dal Col V, Posocco P, Ziarelli F, Fermeglia M, Zhang CC, Pricl S, Peng L. | 2011;13:2924-7. | Organic Letters |  | 2-difluoromethylene-4-methylenepentanoic acid, a paradoxical probe able to mimic the signaling role of 2-oxoglutaric acid in cyanobacteria. | 442 | 2010 | Tonelli M., Simone M., Tasso B., Novelli F., Boido V., Sparatore F., Paglietti G., Pricl S., Giliberti G., Blois S., Ibba C., Sanna G., Loddo R., La Colla P. | 18:2937-2953 (2010) | Bioorganic & Medicinal Chemistry |  | Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives | 448 | 2010 | Giliberti G., Ibba C., Marongiu E., Loddo R., Tonelli M., Boido V., Laurini E., Posocco P., Fermeglia M., Pricl S. | 18:6055-6068 (2010) | Bioorganic & Medicinal Chemistry |  | Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase | 436 | 2010 | Tonelli M., Boido V., La Colla P., Loddo R., Posocco P., Paneni M.S., Fermeglia M., Pricl S. | 18:2304-2316 (2010) | Bioorganic & Medicinal Chemistry |  | Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV) | 439 | 2010 | Laurini E., Zampieri D., Mamolo M.G., Vio L., Zanette C., Florio C., Posocco P., Fermeglia M., Pricl S. | 20:2954-2957 (2010) | Bioorganic & Medicinal Chemistry Letters |  | A 3D-Pharmacophore Model for sigma-2 Receptors Based on a Series of Substituted Benzo[d]oxazol-2(3H)-one Derivatives | 446 | 2010 | S. Pricl,D. L. Gibbons,P. Posocco,E. Laurini,M. Fermeglia,H. M. Kantarjian,M. Talpaz,J. Cortes,M. Young,H. Sun,L. F. Peterson,N. Donato,A. Quintas-Cardama | 116-21:1392-1393 (2010) | Blood | | The Novel BCR-ABL1 V304D Mutation Induces Pan-Tyrosine Kinase Inhibitor Resistance by a Unique Kinase Lateral Escape Mechanism and Is Associated with Very Poor Prognosis In Patients (PTS) with Chronic Myeloid Leukemia (CML) | 445 | 2010 | Posocco P., Pricl S., Jones S., Barnard A., Smith D.K. | 1:393-404 (2010) | Chemical Science |  | Less is more: multiscale modelling of self-assembling multivalency and its impact on DNA binding and gene
delivery | 440 | 2010 | Pavan G.M., Posocco P., Tagliabue A., Maly M., Malek A., Danani A., Ragg E., Catapano C.V., Pricl S. | 16:7781-7795 (2010) | Chemistry - A European Journal |  | PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights | 441 | 2010 | Jones S.P., Pavan G.M., Danani A., Pricl S., Smith D.K. | 16:4519-4532 (2010) | Chemistry - A European Journal |  | Quantifying the Effect of Surface Ligands on Dendron-DNA Interactions: Insights into Multivalency through a Combined Experimental and Theoretical Approach | 444 | 2010 | Posocco P., Fermeglia M., Pricl S. | 20:7742-7753 (2010) | Journal of Materials Chemistry |  | Morphology prediction of block copolymers for drug delivery by mesoscale simulations | 435 | 2010 | Pierotti M.A., Negri T., Tamborini E., Perrone F., Pricl S., Pilotti S. | 4:19-37 (2010) | Molecular Oncology |  | Targeted Therapies: The Rare Cancer Paradigm | 399 | 2009 | Zampieri D., Mamolo M.G., Laurini E., Fermeglia M., Posocco P., Pricl S., Banfi E., Scialino G., Vio, L. | 17:4693-4707(2009) | Bioorganic & Medicinal Chemistry |  | Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations. | 400 | 2009 | Tonelli M., Vazzana I., Tasso B., Boido V., Sparatore F., Fermeglia M., Paneni M.S., Posocco P., Pricl S., La Colla P., Ibba C., Secci B., Collu G., Loddo, R. | 17:4425-4440(2009) | Bioorganic & Medicinal Chemistry |  | Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives. | 437 | 2009 | Carta A., Pricl S., Piras S., Fermeglia M., La Colla,P., Loddo R. | 44:5117-5122 (2009) | European Journal of Medicinal Chemistry |  | Activity and molecular modeling of a new small molecule active against NNRTI-resistant HIV-1 mutants | 424 | 2009 | Zampieri D., Mamolo M., Laurini E., Florio C., Zanette C., Fermeglia M., Posocco P., Paneni M.S., Pricl S., Vio, L. | 52: 5380-5393 (2009) | Journal of Medicinal Chemistry |  | Synthesis, Biological Evaluation and Three-Dimensional in Silico Pharmacophore Model for σ1 Receptor Ligands Based on a Series of Substituted Benzo[d]oxazol-2(3H)-one Derivatives | 366 | 2009 | Negri T., Pavan G.M., Virdis E., Greco A., Fermeglia M., Pricl S., Pierotti M.A., Pilotti S., Tamborini E. | 101: 194-204 (2009) | Journal of National Cancer Institute |  | T670X KIT mutations in gastrointestinal stromal tumors: making sense of missense. | 402 | 2009 | Pavan G.M., Danani A., Pricl S., Smith, D.K. | 131:9686-9694(2009) | Journal of the American Chemical Society |  | Modeling the multivalent recognition between dendritic molecules and DNA: Understanding how ligand "sacrifice" and screening can enhance binding. | 438 | 2009 | Conca E., Negri T., Gronchi A., Fumagalli E., Tamborini E., Pavan G.M., Fermeglia M., Pierotti M. A., Pricl S., Pilotti S. | 8:2491-2495 (2009) | Molecular Cancer Therapeutics | | Activate and resist: L576P-KIT in GIST | 394 | 2008 | Posocco P., Pavan G., Scocchi G., Handgraaf J.W., Malek A., Maly M., Fermeglia M., Fraaije J., Catapano V., Danani A., Pricl S. | 57: 154-159 (2008) | Advances in Science and Technology |  | Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents | 387 | 2008 | Tonelli M., Boido V., Canu C., Sparatore A., Sparatore F., Paneni M.S., Fermeglia M., Pricl S., La Colla P., Casula L., Ibba C., Collu D., Loddo R. | 16: 8446-8465 (2008) | Bioorganic & Medicinal Chemistry |  | Antimicrobial and cytotoxic arylazoenamines. Part III: Antiviral activity of selected classes of arylazoenamines. | 368 | 2008 | Mazzei M., Nieddu E., Mielea M., Balbia, A., Ferrone M., Fermeglia M., Mazzei M.T., Pricl S., LaColla P., Marongiu F., Ibba C., Loddo R. | 16:2591-2605 (2008) | Bioorganic & Medicinal Chemistry |  | Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae | 426 | 2008 | Angusti A., Manfredini S., Durini E., Ciliberti N., Vertuani S., Solaroli N., Pricl S., Ferrone M., Fermeglia M., Loddo R., Secci B., Visioli A., Sanna T., Collu G., Pezzullo M., La Colla P. | 56: 423-432 (2008) | Chemical and Pharmaceutical Bulletin | | Design, synthesis and anti flaviviridae activity of N6-, -O- and 5 O-substituted adenine nucleoside analogs | 401 | 2008 | Carta A., Piras S., Paglietti G., Pricl S., La Colla, P., Busonera B., Loddo, R. | 4:194-205(2008) | Medicinal Chemistry | | 2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: A new class of P-glycoprotein-mediated drug efflux inhibitors. | 403 | 2008 | McAuliffe J.C., Wang W.-L., Pavan G.M., Pricl S., Yang D., Chen S.S., Lazar A.J.F., Pollock R.E., Trent J.C. | 2:161-163(2008) | Molecular Oncology | | Unlucky number 13? Differential effects of KIT exon 13 mutation in gastrointestinal stromal tumors. | 365 | 2008 | Pricl S., Pavan G.M., Negri T., Fermeglia M., Pierotti M.A., Pilotti S., Tamborini E. | xx:xx-xx (2008) | Oncogene | | The long and winding road of the KIT juxtamembrane (JXM) domain | 370 | 2007 | Zampieri D., Mamolo M.G., Vio L., Banfi E., Scialino G., Fermeglia M., Ferrone M., Pricl S. | 15:7444-7458 (2007) | Bioorganic & Medicinal Chemistry |  | Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P45014DM by molecular docking and MM/PBSA method. | 337 | 2007 | Carta A., Loriga M., Paglietti G., Ferrone M., Fermeglia M., Pricl S., Sanna T., Ibba C., La Colla P., Loddo R. | 15: 1914-1927 (2007) | Bioorganic & Medicinal Chemistry |  | Design, synthesis and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against a single-stranded positive sense RNA genome viruses | 349 | 2007 | Posocco P., Ferrone M., Fermeglia M., Pricl S. | 40: 2257-2266 (2007) | Macromolecules |  | Binding at the core. Computational study of structural and ligand binding properties of naphthiridine based dendrimers | 305 | 2006 | Pricl S., Ferrone M., Cosoli P., Paneni M.S., Fermeglia M., Cosentino C., Amato F., Cheng M.C.C., Ferrari M. | 53: 79-84 (2006) | Advances in Science and Technology |  | Release of Proteins from Nanochannel Delivery Systems: a Coupled Many-Scale Simulation - Experimental Investigation | 313 | 2006 | Toth R., Ferrone M., Miertus S., Chiellini E., Fermeglia M., Pricl S. | 7: 1714-1719 (2006) | Biomacromolecules |  | Structure and energetics of biocompatible polymer nanocomposite sistems: a molecular dynamics study | 318 | 2006 | Pricl S., Ferrone M., Fermeglia M., Amato F., Cosentino C., Cheng M.M.C., Walczak R., Ferrari M. | 8: 277-290 (2006) | Biomedical Microdevices |  | Multiscale modeling of protein transport in silicon membrane nanochannels. Part 1. Derivation of molecular parameters from computer simulations | 319 | 2006 | Pricl S., Ferrone M., Fermeglia M., Amato F., Cosentino C., Cheng M.M.C., Walczak R., Ferrari M. | 8: 291-298 (2006) | Biomedical Microdevices |  | Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model | 312 | 2006 | Scialino G., Banfi E., Zampieri D., Mamolo M., Vio L., Ferrone M., Fermeglia M., Paneni M.S., Pricl S. | 58: 76-84 (2006) | Journal of Antimicrobial Chemoterapy |  | Antifungal and antimycobacterial activity of new imidazole and triazole derivatives. A combined and computational approach | 339 | 2006 | Pricl S., Tamborini E., Pierotti M., Pilotti S. | 98: 1583-1584 (2006) | Journal of National Cancer Institute |  | Letter to the editor: Response of a KIT-Positive Extra-abdominal Fibromatosis to Imatinib Mesylate and KIT Genetic Analysis | 340 | 2006 | Carta A., Loriga G., Pirasa S., Paglietti G., La Colla P., Collu G., Piano M.A., Loddo R., Ferrone M., Fermeglia M., Pricl S. | 2: 577-589 (2006) | Medicinal Chemistry |  | Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides | 311 | 2006 | Ferrone M., Perrone F., Tamborini E., Paneni M.S., Fermeglia M., Suardi S., Pastore E., Delia D., Pierotti M.A., Pricl S., Pilotti S. | 5(6):1467-73 (2006) | Molecular Cancer Therapeutics |  | Functional analysis and molecular modelling show a preserved wild type activity of p53 C238Y | 300 | 2006 | Tamborini E., Pricl S., Negri T., Lagonigro M.S., Miselli F., Greco A., Gronchi A., Casali P., Ferrone M., Fermeglia M., Pierotti M.A., Pilotti S. | 25: 6140-6146 (2006) | Oncogene |  | Functional analyses and Molecular modeling of two c-Kit mutations responsible for Imatinib secondary resistance in GIST patients | 286 | 2005 | Mamolo M.G., Zampieri D., Vio L., Fermeglia M., Ferrone M., Pricl S., Scialino G., Banfi E. | 13: 3797-3809 (2005) | Bioorganic & Medicinal Chemistry |  | Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modelling investigations | 282 | 2005 | Tamborini E., Gabanti E., Lagonigro M.S., Negri T., Pricl S., Pierotti M.A., Pilotti S. | 65: 1115 (2005) | Cancer Research |  | KIT/Val654Ala receptor detected in one imatinib-resistant GIST patient. | 293 | 2005 | Pricl S., Ferrone M., Paneni M.S., Fermeglia M.,Tamborini E., Negri T., Lagonigro M.S., Miselli F., Greco A., Pierotti M.A., Pilotti S. | 11: 9032s (2005) | Clinical Cancer Research |  | T670X kit mutations in gastrointestinal stromal tumors: making sense of missense | 303 | 2005 | Ferrone M., Pricl S., Fermeglia M., Paneni M.S., Angusti A., Ciliberti N., Buzzoni L., Durini E., Vertuani S., Manfredini S., Loddo R., La Colla P. | 1: 32-33 (2005) | Global Antiviral Journal |  | Three-dimensional Pharmacophore Modeling of Hindered Nucleoside Analogs (HNAs) as Inhibitors of the Hepatitis C virus NS5B Polymerase | 304 | 2005 | Pricl S., Fermeglia M., Ferrone M., Paneni M.S., Cosoli P., Costi R., Roux A., Artico M., Di Santo R. | 1: 36-37 (2005) | Global Antiviral Journal |  | Novel Aryl Diketo Acids (ADKs) as Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA-Polymerase: Better Understanding Through Molecular Modeling | 322 | 2005 | Angusti A., Auzzas L., Boido V., Canu C., Carta A., Ciliberti N., Ferrone M., Loddo R., La Colla P., Loriga M., Manfredini S., Mazzei M., Nieddu E., Paglietti G., Paneni M.S., Pricl S., Rassu G., Sparatore F., Tasso B., Vitale G. | 1: 37-38 (2005) | Global Antiviral Journal |  | Non-nucleoside anti-Flaviviridae agents from different molecular classes: a jointed experimental/modeling effort | 257 | 2005 | Manfredini S., Angusti A., Ciliberti N., Durini E., Vertuani S., Buzzoni L., Coslanich A., Fermeglia M., Ferrone M., Paneni M.S., Pricl S., La Colla P., Sanna G., Cadeddu A., Mura M., Loddo R. | [ISBN: 978-0-9754188-1-9]: 279-318 (2005) | In "Framing the knowledge of viral hepatitis", edited by Rymond F. Schinasi, IHL Press, Arlington MA, US (2005) | | Hindered nucleoside analogs as hinibitors of HCV RNA-dependent RNA-polymerase: evolving vistas | 288 | 2005 | Di Santo R., Fermeglia M., Ferrone M., Paneni M.S., Costi R., Artico M., Roux A., Gabriele M., Tardiff K.D., Siddiqui A., Pricl S. | 48:6304-6314 (2005) | Journal of Medicinal Chemistry |  | A simple but effective three-dimensional chemical feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA-polymerase inhibitors | 287 | 2005 | Fermeglia M., Ferrone M., Tamborini E., Pricl S. | 4: 1167-1174 (2005) | Molecular Cancer Therapeutics |  | TT315I mutated bcr-abl in chronic myeloid leukemia and imatinib: insights from a computational study | 235 | 2004 | Mamolo M.G., Zampieri D., Falagiani V., Vio L., Fermeglia M., Ferrone M., Pricl S., Banfi E., Scialino G. | 5:231-250 (2004) | Arkivoc |  | Antifungal and antimycobacterial activity of new N1-[1-aryl-2-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-ethylidene]-pyridine-2-carboxamidrazone derivatives | 259 | 2004 | Metullio L., Ferrone M., Coslanich A., Fuchs S., Fermeglia M., Paneni M.S., Pricl S. | 5:1371-1378 (2004) | Biomacromolecules |  | Polyamidoamine (yet not PAMAM) Dendrimers as Bioinspired Materials for Drug Delivery: Structure-Activity Relationships by Molecular Simulations | 186 | 2004 | Frecer, V., Kabelac, M., De Nardi, P., Pricl, S., Miertus, S. | 22: 209-220 (2004) | Journal of Molecular Graphics and Modelling |  | Structure-based design of inhibitors of NS3 serine protease of hepatitis C virus | 281 | 2004 | Manfredini S., Angusti A., Veronese A.C, Durini E., Vertuani S., Nalin F., Solaroli N., Ferrone M., Pricl S., Mura M., Piano M.A, Poddesu B., Cadeddu A., La Colla P., Loddo R. | 76:1007-1015 (2004) | Pure and Applied Chemistry |  | Hindered Nucleoside Analogs (HNA) as Antiflaviviridae Agents | 191 | 2003 | Manfredini S., Solaroli N., Porcu L., Durini E., Angusti A., Vertuani S., Verri A., Spadai S., Focher F., Ferrone M., Pricl, S., De Clercq E., Balzarini J. | 14: 183-194 (2003) | Antiviral Chemistry & Chemotherapy |  | Design, Synthesis and Activity of Phosphonoacetic Acid (Ppa) Ester and Amide Bioisosters of Ribofuranosylnucleoside Diphosphates as Potential Ribonucleotide Reductase Inhibitors. | 234 | 2003 | Caliceti P., Salmaso S., Carofiglio T., Fornasier R., Fermeglia M., Ferrone M., Pricl S. | 14: 899-908 (2003) | Bioconjugate Chemistry |  | Synthesis and physico-chemical characterization of folate-cyclodextrin bioconjugate for active drug delivery | 185 | 2003 | Fermeglia M., Ferrone M., Lodi A., Pricl S. | 53: 15-44 (2003) | Carbohydrate Polymers |  | Host-guest inclusion complexes between anticancer drugs and beta-cytclodextrin: computational studies. | 239 | 2003 | F. Felluga, G. Pitacco, E. Valentin, A. Coslanich, M. Fermeglia, M. Ferrone, and S. Pricl | 14: 3385-3399 (2003) | Tetrahedron: Asymmetry |  | Studying enzyme enantioselectivity using combined ab initio and free energy calculations: alfa-chymotrypsin and methyl cis- and trans-5-oxo-2-pentylpirrolidine-3-carboxylates | 175 | 2002 | Fermeglia M., Ferrone M., Pricl S | 10: 2471-2478 (2002) | Bioorganic & Medicinal Chemistry |  | Computer-aided simulation of a dendrimer with a protoporphyrinic core as potential, novel hemoprotein mimic. | 189 | 2002 | Felluga, F., Fermeglia, M., Ferrone, M., Pitacco, G., Pricl, S., Valentin, E. | 13: 475-489 (2002) | Tetrahedron: Asymmetry |  | Computational studies on the enantioselectivity of alpha-chymotrypsin towards beta-carbomethoxy-gamma-lactams. | 177 | 2001 | Fermeglia, M., Ferrone, M., Gelmetti, S., Pricl, S., | 55: 19-26 (2001) | AIM Magazine |  | I dendrimeri, un esempio di molecole biotecnologiche. | 147 | 2001 | S. Pricl, M. Fermeglia | 45: 23-33 (2001) | Carbohydrate Polymers |  | Molecular simulations of host-guest inclusion compounds: an approach to the lactodendrimers case | 184 | 2001 | Felluga, F., Pitacco, G., Prodan, M., Pricl, S., Visintin, M., Valentin, E. | 12: 3241-3249 (2001) | Tetrahedron: Asymmetry |  | A chemoenzymatic approach to the synthesis of enantiomerically pure aza analogues of paraconic acid methyl ester and both enantiomers of methyl beta-proline. | 102 | 1996 | Fele L., Fermeglia M. | 41: 331-334 (1996) | Journal of Chemical & Engineering Data |  | Partition of proteins in poly(ethylene glycol) - dextran - water system at 298 K. | 428 | 1994 | Grassi, M., Lapasin, R., Pricl, S., Colombo, I., Adrover, A., Giona, M. | 1:533-534(1994) | Proceedings of the Controlled Release Society | | Release from a scleroglucan hydrogel matrix |
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