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MOSE's Life Science Research Projects
DBD_COSTDendrimers in Biomedicine, a COST Action

Project Coordination: Pricl
Project Period: 2009 - 2013
Financial Support: EU-FP7
Web Site:  
The Action is a trans-domain project on the frontiers of nano-chemistry and biomedicine. The main idea is to improve existing therapies, and to find new therapeutic approaches where none exist, by employing novel “smart” nanomaterials – dendrimers. The main objective of the Action is to build a multidisciplinary European network, devoted to the development of novel dendrimers and novel applications, that can compete internationally within this emerging field. This will be achieved by supporting meetings, short-term scientific missions, workshops, training schools and conferences. Successful drug design is not likely to be achieved by a single research group; interdisciplinary co-operation is needed, in particular between biologists and chemists. The success of the network will require free communication among members about their current activities, allowing best practice to be disseminated and materials to be exchanged among the collaborating groups. The COST Action will be a breakthrough event in the dendrimer field for European researchers. It will strengthen European efforts in the face of North American, Australian and Asiatic competition. A COST Action appears to be the best instrument to support these activities. All research groups involved in this Action have financial support for their research, but networking is needed.
PRIN09_SPEngineering of porous materials for biomedical applications

Project Coordination: Sabrina Pricl
Project Period: 2010 - 2012
Financial Support: MIUR
Web Site:  
Several actual biotechnological approaches require the use of biocompatible and biodegradabile polymeric materials with specific morphological-structural properties defined at the micro and mesoscopic level. The requirements of proper characteristics like pore size and shape, degree of porosity and interconnectivity as well as time and rate of degradation are among the most demanding challenges that new biotechnologies issue to materials science. The control of porosity and degradation rate is particularly important for materials used as scaffold for tissues repair and for controlled drug delivery. For these applications, among the most promising in biomedicine, material engineering plays a key role in view of the complexity and multiplicity of functions and the strict requirements needed. Main issues are related not only to biological (biocompatibility and toxicity) properties but also to the optimization of chemical-physical and morphological characteristics of materials used nowadays in biomedical field. This requires a better investigation on the existing correlations between material structural and morphological organization and chemical-physical properties combined with the development of novel technologies able to produce materials with controlled morphological and structural characteristics. The aim of this project is to explore the possibility to realize degradable polymeric matrices in the form of thin sheets and microparticles with well defined porosity in terms of degree of voids, pore interconnection and size as well as with defined degradation rate. The technique of choice to produce these matrices is based on thermally induced phase separation starting from polymers widely used in biomedical field. In particular, porous poly(L-lactide) (PLLA) matrices will be produced by cooling polymer/dioxane/water solutions, on the base of a protocol already tested in the literature. The control of pore size, degree of void and interconnectivity will be achieved by tailoring the composition of the starting solution and by controlling the thermal history of the system. A theoretical and experimental systematic study of thermodynamic and kinetic aspects governing the separation process will lead to the elaboration of predictive models, able to support and guide the testing, and to define thermodynamic and kinetic parameters that control the process in order to extend the technology to several polymer-solvent systems. The scope is to engineer both thin sheets (2mm) with highly interconnected pores with a diameter larger than 20 μm for tissue engineering applications and microparticles with pores of small size (lower then 3 μm) and close porosity to encapsulate active principles.
MS05Development of molecular modelling protocols to support clinical activity

Project Coordination: Pricl
Project Period: 2005 - 2007
Financial Support: Ministry Health
Web Site:  
AIRC04Pathogenetic pathways determining pharmacological response:a novel tumoral functional classification approach

Project Coordination: Pricl
Project Period: 2004 - 2005
Financial Support: AIRC
Web Site:  
FIRB02_SPDevelopment of new antiviral drugs my molecualr modelling

Project Coordination: Pricl
Project Period: 2003 - 2005
Financial Support: M Industria
Web Site:  
PRIN01_SPMolecular modelling for the development of anti viral drugs

Project Coordination: Pricl
Project Period: 2001 - 2002
Financial Support: Ministry of University - Italy
Web Site: